# Reading list

> Studies gathered at Wellness Clinics America — The Wellness Clinics America reading list gathers the semaglutide trial reports and safety review behind the site’s accounts of distinct study populations.

The trials gather very different groups of people. These reports are where their diagnoses, comparisons and outcomes can be examined together.

## STEP 5 and STEP 1

The [STEP 5 report](https://pubmed.ncbi.nlm.nih.gov/36216945/) follows a weight question over two years in adults with overweight or obesity. [STEP 1](https://pubmed.ncbi.nlm.nih.gov/33567185/) supplies an earlier weight comparison in adults with overweight or obesity without diabetes.

## Cardiovascular reports

[SELECT](https://pubmed.ncbi.nlm.nih.gov/37952131/), [SUSTAIN-6](https://pubmed.ncbi.nlm.nih.gov/27633186/) and [STEP-HFpEF](https://pubmed.ncbi.nlm.nih.gov/37622681/) ask distinct cardiovascular questions. [FLOW](https://pubmed.ncbi.nlm.nih.gov/38785209/) brings diabetes and chronic kidney disease together.

## Tissue, consumption and tolerability

The [ESSENCE report](https://pubmed.ncbi.nlm.nih.gov/40305708/) supplies the liver-biopsy findings. The [alcohol use disorder trial](https://pubmed.ncbi.nlm.nih.gov/39937469/) concerns consumption and heavy drinking. The [safety review](https://pubmed.ncbi.nlm.nih.gov/34305810/) adds the treatment difficulties discussed across these pages.

The diagnoses in these titles are indispensable to me. They are a useful antidote to my own temptation to gather every interesting finding under the comfortable word wellness.

## References

[1] Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial https://pubmed.ncbi.nlm.nih.gov/36216945/
[2] Once-Weekly Semaglutide in Adults with Overweight or Obesity https://pubmed.ncbi.nlm.nih.gov/33567185/
[3] Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes https://pubmed.ncbi.nlm.nih.gov/37952131/
[4] Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/27633186/
[5] Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/38785209/
[6] Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis https://pubmed.ncbi.nlm.nih.gov/40305708/
[7] Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/39937469/
[8] Safety of Semaglutide https://pubmed.ncbi.nlm.nih.gov/34305810/
[9] Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity https://pubmed.ncbi.nlm.nih.gov/37622681/

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Wellness Clinics America is my research reading room, where published research gets a closer look at its participants; this is not a clinic or a business, and none of it is medical advice.